Erscheinungsdatum: 01.12.1975, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Microsurgical Neuro-Vascular Anastomoses, Titelzusatz: for Transplantation of Composite Bone and Muscle Grafts An Experimental Study, Auflage: Softcover reprint of the original 1st ed. 1976, Autor: Tschopp, H. M., Verlag: Springer Berlin Heidelberg // Springer Berlin, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 64, Informationen: Paperback, Gewicht: 183 gr, Verkäufer: averdo
Microsurgical Neuro-Vascular Anastomoses ab 117.49 EURO for Transplantation of Composite Bone and Muscle Grafts An Experimental Study. Softcover reprint of the original 1st ed. 1976
Stem cell treatments are a type of intervention strategy that introduces new cells into damaged tissue in order to treat disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering.The ability of stem cells to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities,offers significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects.Nevertheless, before stem cell therapeutics can be applied in the clinical setting, more research is necessary to understand stem cell behavior upon transplantation as well as the mechanisms of stem cell interaction with the diseased/injured micro environment.Medical researchers anticipate that adult and embryonic stem cells will soon be able to treat cancer, Type 1 diabetes mellitus, Parkinson's disease, Huntington's disease, Celiac Disease, cardiac failure, muscle damage and neurological disorders, and many others.This research project is done by two authors Pandey.P and Raghav Krishna.jm
Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNF -stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV, however, this study had a small number of patients, therefore further investigations are needed to confirm these findings.
The book is focused on experimental and clinical studies indicating importance of L-arginine both in local and systemic response to the injury. Thus, increased nitric oxide formation followed by increased arginase activity induced relative lack of arginine at the wound site during healing, while nitric oxide overproduction promptly depleted arterial L-arginine early after blast injury. Muscle ischemic injuries decreased arginine level in uninjured muscles as general response to the severe local injury. An early abrupt decrease in plasma arginine and simultaneous reduction in glomerular filtration rate in living kidney donors were observed after unilateral nephrectomy, while renal transplantation promptly restored excretory function but disturbed L-arginine metabolism persisted in patients during the early period after surgery. Moreover, impaired balance between arginine utilization and release/ resynthesis from endogenous sources disturbed whole body nutritional status, particularly after severe injuries. Our findings as well as the data reported by others confirmed key roles of L-arginine in trauma and inflammation. Beneficial effects of its supplementations support this opinion.
The facial nerve is second only to the vagus as the "busiest" cranial nerve in the human body. It is the part of the highly specialized nervous system and is genetically programmed to perform in a specific fashion. As the techniques of microsurgical nerve repair have become established , it appears that improved clinical results will be independent of further refinements in surgical technique. The technology of muscle transplantation into the paralyzed face has undergone significant improvements over the past decades , with corresponding improvements in the clinical efficacy of the technique.
As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells, Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier's disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained, these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated.