Erscheinungsdatum: 01.12.1975, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Microsurgical Neuro-Vascular Anastomoses, Titelzusatz: for Transplantation of Composite Bone and Muscle Grafts An Experimental Study, Auflage: Softcover reprint of the original 1st ed. 1976, Autor: Tschopp, H. M., Verlag: Springer Berlin Heidelberg // Springer Berlin, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 64, Informationen: Paperback, Gewicht: 183 gr, Verkäufer: averdo
Microsurgical Neuro-Vascular Anastomoses ab 117.49 EURO for Transplantation of Composite Bone and Muscle Grafts An Experimental Study. Softcover reprint of the original 1st ed. 1976
Stem cell treatments are a type of intervention strategy that introduces new cells into damaged tissue in order to treat disease or injury. Many medical researchers believe that stem cell treatments have the potential to change the face of human disease and alleviate suffering.The ability of stem cells to self-renew and give rise to subsequent generations with variable degrees of differentiation capacities,offers significant potential for generation of tissues that can potentially replace diseased and damaged areas in the body, with minimal risk of rejection and side effects.Nevertheless, before stem cell therapeutics can be applied in the clinical setting, more research is necessary to understand stem cell behavior upon transplantation as well as the mechanisms of stem cell interaction with the diseased/injured micro environment.Medical researchers anticipate that adult and embryonic stem cells will soon be able to treat cancer, Type 1 diabetes mellitus, Parkinson's disease, Huntington's disease, Celiac Disease, cardiac failure, muscle damage and neurological disorders, and many others.This research project is done by two authors Pandey.P and Raghav Krishna.jm
The book is focused on experimental and clinical studies indicating importance of L-arginine both in local and systemic response to the injury. Thus, increased nitric oxide formation followed by increased arginase activity induced relative lack of arginine at the wound site during healing, while nitric oxide overproduction promptly depleted arterial L-arginine early after blast injury. Muscle ischemic injuries decreased arginine level in uninjured muscles as general response to the severe local injury. An early abrupt decrease in plasma arginine and simultaneous reduction in glomerular filtration rate in living kidney donors were observed after unilateral nephrectomy, while renal transplantation promptly restored excretory function but disturbed L-arginine metabolism persisted in patients during the early period after surgery. Moreover, impaired balance between arginine utilization and release/ resynthesis from endogenous sources disturbed whole body nutritional status, particularly after severe injuries. Our findings as well as the data reported by others confirmed key roles of L-arginine in trauma and inflammation. Beneficial effects of its supplementations support this opinion.
Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNF -stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV, however, this study had a small number of patients, therefore further investigations are needed to confirm these findings.
Human cell culture is not a new topic, but the development of new molecular techniques and reagents which can be used to investigate cell function and the responsible intracellular mechanisms make it a continuing requirement. This third edition of Human Cell Culture Protocols expands upon the previous editions with current, detailed protocols for the isolation and culture of a range of primary cells from human tissues. With new chapters on pancreatic cells needed for basic studies on the pathogenesis of diabetes and for their application for islet transplantation, the book also delves into protocols for hepatocytes, skin cells, lung cells, parathyroid cells, gastric cells, renal cells, adipocytes, ovarian cells, bone cells, vascular smooth muscle cells, vascular endothelial cells, regulatory T cells, blood mononuclear cells, as well as new techniques being applied to human cell culture, particularly the use of biocompatible scaffolds to grow cells, the in vitro use of laser microdissection to isolate cells from culture, and automated cell culture. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Human Cell Culture Protocols, Third Edition makes it possible for a worker with basic cell culture training, whether in the fields of cell biology, gene therapy, and cell transplantation, to prepare cell cultures of the specific cell type necessary to forward their vital research.
This book provides up-to-date knowledge on all aspects of the multidisciplinary approach to pulmonary rehabilitation that is essential in order to achieve optimal results. It will be an ideal resource especially for pulmonologists in training, but will also be of value for physiotherapists, other health care professionals, and technicians. Detailed information is presented on the diverse program components in pulmonary rehabilitation, with clear explanation of the roles of the nutritionist, psychologist, occupational therapist, respiratory nurse, and physical activity coach. Guidance is provided on identification of candidates for pulmonary rehabilitation and on all aspects of assessment, including exercise capacity, muscle function, and physical activity. Patient-centered, economic, and other outcomes are examined, with separate discussion of combined outcome assessment. Furthermore, due consideration is given to organizational aspects of pulmonary rehabilitation and to rehabilitation in specific scenarios, e.g., thoracic oncology and surgery, transplantation, and the ICU. The authors are internationally recognized experts selected for their expertise in the topics they discuss.